TNFSF4

Across TCGA patient cohorts, TNFSF4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF4-associated genes across cancer lineages are S6_pS240_S244, Caspase-7-cleavedD198, and FASN. Each is linked with TNFSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF4-to-partner and partner-to-TNFSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by TNFSF4-low versus TNFSF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF4→partner) and Y-score (partner→TNFSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.400	+2.459	.041	.020	3	2
UCEC	Caspase-7-cleavedD198 →	+0.984	+3.584	<.001	.002	3	2
UCEC	FASN →	+0.396	+2.459	.037	.020	3	1
UCEC	Notch1 →	+0.155	+3.009	.022	.019	3	1
UCEC	PCNA →	+0.307	+3.584	.003	.002	3	1
UCEC	PDCD4 →	-0.588	-2.999	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

S6_pS240_S244 by TNFSF4 expression — UCEC

Explore this box plot interactively →