TNFSF4

Across TCGA pan-cancer cohorts, TNFSF4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TNFSF4 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TNFSF4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNFSF4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

KIRP, SKCM, and MESO are the cancer types where TNFSF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.449	0.695	<.001	155	view →
SKCM	OS	Median	All	0.415	0.255	<.001	97	view →
MESO	OS	Median	All	0.255	0.514	<.001	90	view →
ACC	DFS	Median	All	0.500	0.813	<.001	63	view →
DLBC	OS	Median	All	0.492	1.000	.001	53	view →
LIHC	OS	Tertile	All	0.580	0.769	<.001	52	view →
HNSC	DFS	Tertile	III,IV	0.721	0.577	.006	29	view →
THCA	DFS	Quartile	II,III,IV	0.601	0.974	.004	22	view →
LAML	DFS	Tertile	All	0.301	0.597	.004	22	view →
LGG	DFS	Quartile	All	0.749	0.872	.002	21	view →
UCS	DFS	Tertile	II,III,IV	0.645	0.317	.020	20	view →
LUAD	DFS	Median	IV	0.745	0.254	.010	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TNFSF4–KIRP (DFS)

Open the KIRP breakdown →