TNFSF4

Across TCGA pan-cancer cohorts, TNFSF4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TNFSF4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNFSF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFSF4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where TNFSF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFSF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.641	<.001	12	view →
KIRC	Male	IV	+0.977	<.001	11	view →
LUAD	Female	II,III,IV	+1.295	<.001	9	view →
STAD	All	II,III,IV	+1.208	<.001	9	view →
COAD	Male	II,III,IV	+1.054	<.001	9	view →
KICH	Male	All	−0.875	<.001	8	view →
LIHC	All	II,III,IV	+0.865	<.001	7	view →
BRCA	All	III,IV	+1.774	<.001	6	view →
LUSC	All	All	+0.814	<.001	4	view →
CHOL	All	All	+1.492	.004	2	view →
BLCA	Female	All	+0.922	.026	2	view →
THCA	All	III,IV	+0.764	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TNFSF4–HNSC

Open the HNSC breakdown →