TNFSF4

Across TCGA cell cohorts, TNFSF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,999 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFSF4-associated GO terms across cancer lineages are Regulation of T cell costimulation, Positive regulation of ER to Golgi vesicle-mediated transport, and Negative regulation of T-helper 1 cell differentiation. Each is linked with TNFSF4 in more than 7 cancer types. Because this analysis shows association rather than direction, both TNFSF4-to-partner and partner-to-TNFSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of T cell costimulation grouped by TNFSF4-low versus TNFSF4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF4→partner) and Y-score (partner→TNFSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of T cell costimulation →	+0.784	+1.431	<.001	<.001	3	8
BONE	Positive regulation of ER to Golgi vesicle-mediated transport →	+0.125	+0.471	<.001	.003	3	8
SOFT_TISSUE	Negative regulation of T-helper 1 cell differentiation →	+0.990	+2.351	.001	<.001	3	7
BONE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.084	+0.642	.001	.001	3	7
LUNG_NSCLC_LUAD	Golgi to plasma membrane transport →	+0.057	+0.322	<.001	.001	2	8
BONE	Vesicle cargo loading →	+0.133	+0.534	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,999 associations by consensus.

Regulation of T cell costimulation by TNFSF4 expression — BLOOD_Leukemia

Explore this box plot interactively →