TNFSF18

Across TCGA patient cohorts, TNFSF18 mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TNFSF18-associated genes across cancer lineages are CHRNA5, GPR3, and SNRPGP17. Each is linked with TNFSF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF18-to-partner and partner-to-TNFSF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNA5 grouped by TNFSF18-low versus TNFSF18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF18→partner) and Y-score (partner→TNFSF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CHRNA5 →	+0.714	+3.341	.003	.005	3	2
SKCM	GPR3 →	+0.763	+3.328	.009	.005	3	2
UCEC	SNRPGP17 →	+0.420	+2.463	<.001	.008	3	1
UCEC	DPRXP2 →	+0.378	+3.483	.001	.008	3	1
UCEC	MIR8082 →	+0.614	+2.976	<.001	.004	3	1
UCEC	OR6C70 →	+0.054	+3.329	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

CHRNA5 by TNFSF18 expression — SKCM

Explore this box plot interactively →