TNFSF18

Across TCGA pan-cancer cohorts, TNFSF18 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TNFSF18’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TNFSF18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFSF18 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where TNFSF18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFSF18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+1.308	<.001	9	view →
KIRC	Male	IV	+0.801	<.001	8	view →
KICH	All	All	−0.527	.002	5	view →
LUAD	Male	All	+0.585	.004	4	view →
STAD	All	All	+0.471	.012	4	view →
HNSC	All	II,III,IV	+0.720	.009	3	view →
LUSC	Female	III,IV	+1.369	.015	2	view →
CHOL	All	All	+0.597	<.001	2	view →
UCEC	All	All	+0.402	.004	2	view →
READ	All	All	+0.443	.015	1	view →
LIHC	Female	II,III,IV	+0.200	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TNFSF18–THCA

Open the THCA breakdown →