TNFSF18

Across TCGA pan-cancer cohorts, TNFSF18 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TNFSF18 data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TNFSF18 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFSF18 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, CESC, and LIHC are the cancer types where TNFSF18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	III,IV	0.816	0.472	<.001	45	view →
CESC	DFS	Quartile	II,III,IV	0.923	0.632	<.001	42	view →
LIHC	OS	Quartile	All	0.421	0.622	.001	40	view →
STAD	OS	Quartile	All	0.577	0.858	.003	31	view →
ACC	OS	Tertile	III,IV	0.178	0.707	.002	23	view →
LUAD	DFS	Quartile	All	0.882	0.728	<.001	19	view →
LUSC	DFS	Median	II,III,IV	0.682	0.531	.010	18	view →
KIRP	OS	Quartile	All	0.858	0.967	.004	14	view →
PCPG	DFS	Median	All	0.914	0.621	.009	13	view →
KICH	DFS	Tertile	II,III,IV	0.573	0.950	.008	12	view →
UCEC	OS	Tertile	III,IV	0.899	0.789	.013	12	view →
LAML	DFS	Tertile	All	0.430	0.645	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TNFSF18–SKCM (DFS)

Open the SKCM breakdown →