TNFRSF8

Across TCGA patient cohorts, TNFRSF8 mutation is significantly associated with the RNA expression of many other genes, with 3,300 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF8-associated genes across cancer lineages are TVP23BP2, ANKRD20A6P, and NUP50. Each is linked with TNFRSF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF8-to-partner and partner-to-TNFRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TVP23BP2 grouped by TNFRSF8-low versus TNFRSF8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF8→partner) and Y-score (partner→TNFRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TVP23BP2 →	+0.281	+3.602	<.001	.003	3	3
READ	ANKRD20A6P →	+0.261	+5.925	<.001	.002	3	3
UCEC	NUP50 →	+0.527	+4.021	<.001	<.001	3	3
UCEC	MESD →	+0.449	+3.839	<.001	<.001	3	3
UCEC	SRIP3 →	+0.374	+2.002	.002	.001	3	3
SKCM	CCDC134 →	+0.459	+2.945	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,300 associations by consensus.

TVP23BP2 by TNFRSF8 expression — COAD

Explore this box plot interactively →