TNFRSF8

Across TCGA pan-cancer cohorts, TNFRSF8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TNFRSF8 data layer compared with 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TNFRSF8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFRSF8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where TNFRSF8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.759	0.633	<.001	114	view →
UVM	OS	Tertile	II,III,IV	0.386	0.813	<.001	112	view →
SKCM	OS	Tertile	All	0.415	0.239	<.001	86	view →
CESC	DFS	Median	II,III,IV	0.660	0.271	.001	46	view →
UCEC	DFS	Tertile	IV	0.863	0.464	.005	44	view →
LUAD	OS	Tertile	III,IV	0.653	0.338	.008	28	view →
LUSC	DFS	Median	All	0.330	0.447	.003	26	view →
KIRC	DFS	Median	All	0.838	0.903	.010	25	view →
ESCA	DFS	Quartile	II,III,IV	0.489	0.209	.006	24	view →
KIRP	DFS	Tertile	All	0.578	0.938	.003	18	view →
CHOL	DFS	Tertile	All	0.777	0.151	<.001	18	view →
LGG	DFS	Tertile	All	0.337	0.542	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TNFRSF8–HNSC (DFS)

Open the HNSC breakdown →