TNFRSF10C

Across TCGA patient cohorts, TNFRSF10C mutation is significantly associated with the RNA expression of many other genes, with 652 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10C-associated genes across cancer lineages are PGAP2, COX15, and MAT1A. Each is linked with TNFRSF10C in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10C-to-partner and partner-to-TNFRSF10C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAP2 grouped by TNFRSF10C-low versus TNFRSF10C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10C→partner) and Y-score (partner→TNFRSF10C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAP2 →	+0.425	+2.233	.005	.006	3	1
UCEC	COX15 →	+0.431	+2.708	.005	.003	3	1
UCEC	MAT1A →	-1.051	-3.437	.001	.005	3	1
UCEC	KCTD14 →	+0.930	+2.254	.003	.006	3	1
UCEC	SLC25A4 →	+0.570	+2.609	.002	.005	3	1
UCEC	RAD17 →	+0.505	+3.606	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 652 associations by consensus.

PGAP2 by TNFRSF10C expression — UCEC

Explore this box plot interactively →