TNFRSF10C

Across TCGA pan-cancer cohorts, TNFRSF10C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TNFRSF10C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TNFRSF10C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF10C is over-expressed in tumor, although a few such as LUSC and PRAD show the opposite, repressed pattern.

KIRP, COAD, and THCA are the cancer types where TNFRSF10C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF10C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.545	<.001	11	view →
COAD	Male	II,III,IV	+1.031	<.001	9	view →
THCA	Female	All	+1.776	<.001	7	view →
LUSC	Male	II,III,IV	−1.719	<.001	6	view →
LIHC	Female	All	+0.878	<.001	6	view →
CHOL	All	All	+2.331	<.001	5	view →
LUAD	Female	III,IV	+0.963	.014	4	view →
HNSC	Female	All	+0.472	.018	4	view →
STAD	Male	All	+0.701	.010	3	view →
PRAD	All	All	−0.442	.001	2	view →
KIRC	All	All	+0.441	.001	2	view →
READ	All	All	+1.028	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TNFRSF10C–KIRP

Open the KIRP breakdown →