TNFRSF10C

Across TCGA pan-cancer cohorts, TNFRSF10C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TNFRSF10C data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher TNFRSF10C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFRSF10C expression acts as an unfavorable survival marker, although some lineages such as DLBC and HNSC show a favorable association.

DLBC, LGG, and HNSC are the cancer types where TNFRSF10C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	III,IV	0.984	0.146	<.001	45	view →
LGG	OS	Median	All	0.748	0.872	<.001	43	view →
HNSC	DFS	Quartile	IV	0.518	0.259	.007	41	view →
MESO	OS	Quartile	II,III,IV	0.246	0.517	.003	39	view →
LUSC	DFS	Median	All	0.289	0.457	.002	35	view →
UVM	DFS	Median	All	0.394	0.717	.005	34	view →
BLCA	DFS	Tertile	IV	0.084	0.385	<.001	33	view →
CESC	DFS	Tertile	All	0.618	0.800	.002	28	view →
LUAD	DFS	Median	All	0.405	0.282	.007	26	view →
LIHC	OS	Tertile	All	0.669	0.848	.002	25	view →
ESCA	DFS	Median	II,III,IV	0.293	1.000	.002	24	view →
GBM	DFS	Tertile	All	0.159	0.265	.005	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TNFRSF10C–DLBC (DFS)

Open the DLBC breakdown →