TNFRSF10C

Across TCGA patient cohorts, TNFRSF10C mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10C-associated genes across cancer lineages are EGFR_pY1068, GATA6, and N-Ras. Each is linked with TNFRSF10C in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10C-to-partner and partner-to-TNFRSF10C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TNFRSF10C-low versus TNFRSF10C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10C→partner) and Y-score (partner→TNFRSF10C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-2.584	.040	.011	3	1
UCEC	GATA6 →	-0.156	-2.985	.029	.034	3	1
UCEC	N-Ras →	-0.131	-3.302	.018	.010	3	1
UCEC	p62 Lck ligand →	+0.434	+3.179	.004	.010	3	1
UCEC	p70-S6K →	+0.176	+2.611	.049	.006	3	1
UCEC	PRAS40_pT246 →	+0.205	+1.887	.010	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by TNFRSF10C expression — UCEC

Explore this box plot interactively →