TNFRSF10A

Across TCGA patient cohorts, TNFRSF10A mutation is significantly associated with the RNA expression of many other genes, with 2,872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10A-associated genes across cancer lineages are LINC02348, AATF, and DSN1. Each is linked with TNFRSF10A in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10A-to-partner and partner-to-TNFRSF10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02348 grouped by TNFRSF10A-low versus TNFRSF10A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10A→partner) and Y-score (partner→TNFRSF10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02348 →	+0.499	+1.854	<.001	.005	3	2
UCEC	AATF →	+0.423	+4.169	.005	<.001	3	2
UCEC	DSN1 →	+0.612	+3.329	.001	.005	3	2
UCEC	FAM177A1 →	+0.452	+3.354	<.001	.005	3	2
UCEC	NUS1 →	+0.550	+2.436	.001	.002	3	2
UCEC	PPP2R5E →	+0.550	+3.480	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,872 associations by consensus.

LINC02348 by TNFRSF10A expression — UCEC

Explore this box plot interactively →