TNFRSF10A

Across TCGA pan-cancer cohorts, TNFRSF10A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TNFRSF10A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFRSF10A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF10A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where TNFRSF10A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF10A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.982	<.001	11	view →
COAD	Female	II,III,IV	+1.255	<.001	10	view →
THCA	All	III,IV	+0.833	<.001	10	view →
KICH	All	II,III,IV	−1.888	<.001	8	view →
STAD	Male	All	+1.485	<.001	8	view →
HNSC	Male	All	+0.938	<.001	8	view →
LUAD	All	II,III,IV	+0.787	<.001	7	view →
BLCA	Male	III,IV	+1.772	.007	4	view →
CHOL	All	All	+1.846	<.001	3	view →
UCEC	All	III,IV	+1.245	.025	2	view →
READ	All	All	+0.882	.003	2	view →
ESCA	All	All	+1.130	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TNFRSF10A–KIRC

Open the KIRC breakdown →