TNFRSF10A

Across TCGA pan-cancer cohorts, TNFRSF10A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TNFRSF10A data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TNFRSF10A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNFRSF10A expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

MESO, KIRC, and LGG are the cancer types where TNFRSF10A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	II,III,IV	0.265	0.502	.001	105	view →
KIRC	OS	Median	All	0.767	0.496	<.001	84	view →
LGG	OS	Median	All	0.379	0.523	<.001	49	view →
PAAD	OS	Median	All	0.267	0.527	<.001	45	view →
LUAD	DFS	Quartile	All	0.626	0.834	<.001	31	view →
STAD	DFS	Tertile	IV	0.229	0.669	.012	30	view →
LUSC	DFS	Tertile	All	0.299	0.467	.004	18	view →
SKCM	OS	Median	III,IV	0.513	0.276	.001	15	view →
CHOL	DFS	Quartile	II,III,IV	0.754	0.104	.004	15	view →
ACC	DFS	Tertile	All	0.384	0.765	.008	13	view →
SCLC	DFS	Quartile	All	0.543	0.235	.007	12	view →
PRAD	DFS	Tertile	All	0.952	0.887	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TNFRSF10A–MESO (DFS)

Open the MESO breakdown →