TNFRSF10A

Across TCGA patient cohorts, TNFRSF10A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10A-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and ER-alpha_pS118. Each is linked with TNFRSF10A in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10A-to-partner and partner-to-TNFRSF10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TNFRSF10A-low versus TNFRSF10A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10A→partner) and Y-score (partner→TNFRSF10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.599	+2.189	.009	.034	3	2
UCEC	EGFR_pY1068 →	-0.314	-3.321	.004	.009	3	1
UCEC	ER-alpha_pS118 →	-0.328	-3.000	.036	.036	2	2
UCEC	FOXO3a →	-0.091	-2.102	.040	.019	3	1
UCEC	GATA6 →	-0.152	-2.577	.035	.011	3	1
UCEC	JNK2 →	+0.254	+2.834	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Annexin-1 by TNFRSF10A expression — UCEC

Explore this box plot interactively →