TNFRSF10A

Across TCGA cell cohorts, TNFRSF10A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,510 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFRSF10A-associated GO terms across cancer lineages are TRAIL-activated apoptotic signaling pathway, Cellular response to mechanical stimulus, and Cellular response to external stimulus. Each is linked with TNFRSF10A in more than 11 cancer types. Because this analysis shows association rather than direction, both TNFRSF10A-to-partner and partner-to-TNFRSF10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAIL-activated apoptotic signaling pathway grouped by TNFRSF10A-low versus TNFRSF10A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10A→partner) and Y-score (partner→TNFRSF10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRAIL-activated apoptotic signaling pathway →	+0.661	+1.259	.002	.004	3	12
PANCREAS	Cellular response to mechanical stimulus →	+0.106	+1.004	<.001	<.001	3	11
PANCREAS	Cellular response to external stimulus →	+0.113	+1.004	<.001	<.001	3	10
BLOOD_Leukemia	Maturation of 5.8S rRNA →	+0.070	+1.366	<.001	<.001	3	8
BLOOD_Leukemia	Skeletal myofibril assembly →	+0.638	+1.639	<.001	<.001	3	8
LARGE_INTESTINE	Activation of NF-kappaB-inducing kinase activity →	+0.174	+1.114	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,510 associations by consensus.

TRAIL-activated apoptotic signaling pathway by TNFRSF10A expression — LUNG_SCLC

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