TNFAIP6

Across TCGA patient cohorts, TNFAIP6 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFAIP6-associated genes across cancer lineages are RN7SL210P, MIR6854, and SHANK2-AS3. Each is linked with TNFAIP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFAIP6-to-partner and partner-to-TNFAIP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL210P grouped by TNFAIP6-low versus TNFAIP6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP6→partner) and Y-score (partner→TNFAIP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL210P →	+0.294	+5.070	<.001	.008	3	2
BRCA	MIR6854 →	+0.706	+5.575	<.001	.004	3	2
SKCM	SHANK2-AS3 →	+0.024	+3.408	<.001	.009	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1
READ	RNU1-36P →	+0.357	+4.421	<.001	.009	3	1
READ	RNU6-178P →	+0.963	+4.361	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

RN7SL210P by TNFAIP6 expression — BRCA

Explore this box plot interactively →