TNFAIP6

Across TCGA pan-cancer cohorts, TNFAIP6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TNFAIP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFAIP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFAIP6 is over-expressed in tumor.

KIRC, HNSC, and KIRP are the cancer types where TNFAIP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFAIP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+5.579	<.001	12	view →
HNSC	Female	IV	+2.870	<.001	11	view →
KIRP	Male	III,IV	+3.028	<.001	9	view →
COAD	Male	II,III,IV	+1.175	<.001	9	view →
THCA	All	All	+0.809	<.001	7	view →
LUAD	All	II,III,IV	+0.973	.001	6	view →
BRCA	All	All	+0.877	<.001	6	view →
LIHC	All	III,IV	+0.270	.005	6	view →
CHOL	All	All	+3.971	<.001	3	view →
LUSC	Male	All	+0.897	<.001	3	view →
STAD	Male	II,III,IV	+0.981	.014	2	view →
ESCA	All	All	+1.650	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TNFAIP6–KIRC

Open the KIRC breakdown →