TNFAIP3

Across TCGA patient cohorts, TNFAIP3 mutation is significantly associated with the RNA expression of many other genes, with 2,361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFAIP3-associated genes across cancer lineages are TXNP3, LIMK2P1, and RNU6-902P. Each is linked with TNFAIP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFAIP3-to-partner and partner-to-TNFAIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNP3 grouped by TNFAIP3-low versus TNFAIP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP3→partner) and Y-score (partner→TNFAIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXNP3 →	+0.102	+1.975	.001	.007	3	3
UCEC	LIMK2P1 →	+0.068	+1.808	<.001	.002	3	3
SKCM	RNU6-902P →	+0.392	+3.046	<.001	.004	3	3
UCEC	TRAJ11 →	+0.381	+1.983	.002	.001	3	3
UCEC	UHRF1 →	+0.930	+2.403	<.001	<.001	3	2
UCEC	RBBP4P3 →	+0.061	+1.774	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,361 associations by consensus.

TXNP3 by TNFAIP3 expression — UCEC

Explore this box plot interactively →