TNFAIP3

Across TCGA pan-cancer cohorts, TNFAIP3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TNFAIP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFAIP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFAIP3 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and STAD are the cancer types where TNFAIP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFAIP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.716	<.001	11	view →
HNSC	Male	III,IV	+1.575	<.001	10	view →
STAD	All	II,III,IV	+1.001	.001	8	view →
LUSC	All	All	−0.681	.001	5	view →
LIHC	All	II,III,IV	+1.121	.002	4	view →
UCEC	All	All	−1.112	.001	4	view →
THCA	Female	All	−0.937	<.001	4	view →
LUAD	All	All	−0.646	.001	4	view →
CHOL	All	All	+1.891	<.001	3	view →
BLCA	All	All	−1.005	.029	3	view →
ESCA	All	All	+1.317	.008	2	view →
BRCA	All	III,IV	−0.600	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TNFAIP3–KIRC

Open the KIRC breakdown →