TNFAIP3

Across TCGA pan-cancer cohorts, TNFAIP3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TNFAIP3 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TNFAIP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TNFAIP3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and KIRC show a favorable association.

ACC, KIRP, and LGG are the cancer types where TNFAIP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.311	0.807	<.001	108	view →
KIRP	DFS	Tertile	All	0.534	0.924	.004	86	view →
LGG	OS	Median	All	0.738	0.881	<.001	49	view →
ESCA	DFS	Tertile	All	1.000	0.394	.002	39	view →
LIHC	DFS	Median	All	0.257	0.337	.008	28	view →
KIRC	DFS	Median	All	0.846	0.742	.011	24	view →
PAAD	OS	Quartile	II,III,IV	0.651	0.380	.008	16	view →
BRCA	DFS	Tertile	III,IV	0.676	0.412	.010	13	view →
BLCA	DFS	Median	III,IV	0.657	0.485	.002	11	view →
SKCM	DFS	Median	II,III,IV	0.297	0.156	.003	10	view →
CHOL	DFS	Median	All	0.614	0.199	.016	9	view →
UCS	OS	Median	IV	0.752	0.404	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TNFAIP3–ACC (OS)

Open the ACC breakdown →