TNFAIP3

Across TCGA patient cohorts, TNFAIP3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFAIP3-associated genes across cancer lineages are ASNS, FOXO3a_pS318_S321, and MEK1. Each is linked with TNFAIP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFAIP3-to-partner and partner-to-TNFAIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TNFAIP3-low versus TNFAIP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP3→partner) and Y-score (partner→TNFAIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.355	+1.415	.008	.046	3	3
UCEC	FOXO3a_pS318_S321 →	-0.101	-2.000	.030	.029	3	2
UCEC	MEK1 →	+0.381	+2.169	.005	.003	3	2
UCEC	eIF4E →	+0.163	+2.169	.039	.003	3	1
UCEC	eIF4G →	+0.249	+2.321	.032	.033	3	1
UCEC	Heregulin →	-0.100	-1.807	.030	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ASNS by TNFAIP3 expression — UCEC

Explore this box plot interactively →