TNFAIP3

Across TCGA cell cohorts, TNFAIP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,473 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TNFAIP3-associated GO terms across cancer lineages are Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, Negative regulation of osteoclast proliferation, and Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway. Each is linked with TNFAIP3 in more than 18 cancer types. Because this analysis shows association rather than direction, both TNFAIP3-to-partner and partner-to-TNFAIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway grouped by TNFAIP3-low versus TNFAIP3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP3→partner) and Y-score (partner→TNFAIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway →	+0.118	+1.708	.001	.001	3	19
PANCREAS	Negative regulation of osteoclast proliferation →	+1.400	+2.249	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway →	+1.065	+2.666	<.001	<.001	3	18
LARGE_INTESTINE	Protein deubiquitination involved in ubiquitin-dependent protein catabolic process →	+0.137	+1.871	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Canonical NF-kappaB signal transduction →	+0.122	+2.168	.007	.003	2	17
KIDNEY	Regulation of germinal center formation →	+1.115	+1.774	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,473 associations by consensus.

Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway by TNFAIP3 expression — STOMACH

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