TNFAIP3

Across TCGA cell cohorts, TNFAIP3 mutation is significantly associated with the RNA expression of many other genes, with 411 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFAIP3-associated genes across cancer lineages are BANF2, SPATA48, and RTL4. Each is linked with TNFAIP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFAIP3-to-partner and partner-to-TNFAIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by TNFAIP3-low versus TNFAIP3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP3→partner) and Y-score (partner→TNFAIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BANF2 →	+0.229	+4.232	<.001	<.001	3	1
LUNG_SCLC	SPATA48 →	+0.023	+4.584	<.001	<.001	3	1
LUNG_SCLC	RTL4 →	+0.465	+3.866	.002	.002	3	1
LUNG_SCLC	CATSPER4 →	+0.023	+3.602	.008	.005	3	1
BLOOD_Leukemia	RIMS4 →	+0.214	+3.675	.002	.003	3	1
BLOOD_Leukemia	ELMOD1 →	+0.147	+3.557	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 411 associations by consensus.

BANF2 by TNFAIP3 expression — LUNG_SCLC

Explore this box plot interactively →