TNC

Across TCGA patient cohorts, TNC mutation is significantly associated with the RNA expression of many other genes, with 6,114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNC-associated genes across cancer lineages are ADNP2, TIMM44, and EMID1. Each is linked with TNC in more than 4 cancer types. Because this analysis shows association rather than direction, both TNC-to-partner and partner-to-TNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by TNC-low versus TNC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNC→partner) and Y-score (partner→TNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADNP2 →	+0.434	+1.487	<.001	.001	3	5
UCEC	TIMM44 →	+0.366	+1.584	<.001	<.001	3	5
UCEC	EMID1 →	-1.345	-1.541	<.001	<.001	3	5
UCEC	FANCA →	+0.524	+1.684	<.001	<.001	3	5
UCEC	PLA2G3 →	+0.474	+1.807	.002	.003	3	4
COAD	CENPM →	+0.576	+1.722	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,114 associations by consensus.

ADNP2 by TNC expression — UCEC

Explore this box plot interactively →