TNC

Across TCGA pan-cancer cohorts, TNC RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TNC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNC is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where TNC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+3.313	<.001	12	view →
THCA	Male	All	+2.294	<.001	9	view →
KICH	Female	II,III,IV	−4.158	<.001	8	view →
LUAD	All	III,IV	+1.751	<.001	8	view →
LUSC	Male	All	+1.881	<.001	5	view →
KIRC	All	II,III,IV	−0.998	.001	5	view →
CHOL	All	All	+2.605	.006	2	view →
BLCA	Male	All	−1.601	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TNC–HNSC

Open the HNSC breakdown →