TNC

Across TCGA pan-cancer cohorts, TNC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TNC data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TNC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TNC expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

BLCA, MESO, and LGG are the cancer types where TNC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.519	0.709	<.001	58	view →
MESO	OS	Median	III,IV	0.442	0.699	<.001	54	view →
LGG	DFS	Median	All	0.651	0.831	<.001	54	view →
UVM	OS	Tertile	All	0.345	0.769	.016	32	view →
ACC	DFS	Median	All	0.270	0.713	.009	22	view →
ESCA	OS	Median	All	1.000	0.629	.012	17	view →
SKCM	OS	Quartile	All	0.445	0.245	.002	11	view →
STAD	OS	Quartile	All	0.510	0.665	.024	10	view →
UCS	OS	Median	III,IV	0.512	0.215	.026	10	view →
DLBC	DFS	Median	II,III,IV	1.000	0.535	.015	8	view →
THCA	DFS	Median	All	0.914	0.972	.013	8	view →
KICH	DFS	Quartile	All	0.617	1.000	.019	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TNC–BLCA (OS)

Open the BLCA breakdown →