TNC

Across TCGA patient cohorts, TNC mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNC-associated genes across cancer lineages are PCNA, TFRC, and ASNS. Each is linked with TNC in more than 3 cancer types. Because this analysis shows association rather than direction, both TNC-to-partner and partner-to-TNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TNC-low versus TNC-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNC→partner) and Y-score (partner→TNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PCNA →	+0.299	+2.816	.010	.036	3	4
BLCA	TFRC →	+0.392	+2.182	.038	.033	3	4
COAD	ASNS →	+0.374	+1.321	<.001	.024	3	4
UCEC	ATM →	-0.613	-2.070	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.286	+1.584	<.001	<.001	3	4
UCEC	eEF2 →	+0.219	+1.169	.015	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

PCNA by TNC expression — LUSC

Explore this box plot interactively →