TNC

Across TCGA cell cohorts, TNC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,042 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TNC-associated GO terms across cancer lineages are Trophoblast cell migration, Integrin-mediated signaling pathway, and Positive regulation of stress fiber assembly. Each is linked with TNC in more than 13 cancer types. Because this analysis shows association rather than direction, both TNC-to-partner and partner-to-TNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trophoblast cell migration grouped by TNC-low versus TNC-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNC→partner) and Y-score (partner→TNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Trophoblast cell migration →	+0.327	+3.790	<.001	<.001	3	14
BONE	Integrin-mediated signaling pathway →	+0.263	+4.435	<.001	<.001	3	13
BONE	Positive regulation of stress fiber assembly →	+0.197	+4.098	<.001	<.001	3	12
BONE	Elastin metabolic process →	+0.327	+4.575	<.001	<.001	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.268	+4.540	<.001	<.001	3	12
LIVER	Regulation of protein processing →	+0.217	+5.999	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,042 associations by consensus.

Trophoblast cell migration by TNC expression — BONE

Explore this box plot interactively →