TNC

Across TCGA cell cohorts, TNC mutation is significantly associated with the RNA expression of many other genes, with 1,707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNC-associated genes across cancer lineages are PLEKHM2, MGRN1, and VPS37D. Each is linked with TNC in more than 2 cancer types. Because this analysis shows association rather than direction, both TNC-to-partner and partner-to-TNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHM2 grouped by TNC-low versus TNC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNC→partner) and Y-score (partner→TNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLEKHM2 →	+0.587	+2.115	.002	.004	3	3
SKIN	MGRN1 →	+0.672	+2.714	.003	.002	3	3
LARGE_INTESTINE	VPS37D →	+0.676	+3.386	<.001	.001	3	3
LARGE_INTESTINE	ZNF771 →	+0.457	+2.064	.006	.004	3	3
LARGE_INTESTINE	EHMT2 →	+0.443	+1.850	.007	.006	3	3
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

PLEKHM2 by TNC expression — LARGE_INTESTINE

Explore this box plot interactively →