TMPRSS4

Across TCGA cell cohorts, TMPRSS4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMPRSS4-associated genes across cancer lineages are KRTAP21-2, DEFB4B, and CNMD. Each is linked with TMPRSS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS4-to-partner and partner-to-TMPRSS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP21-2 grouped by TMPRSS4-low versus TMPRSS4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS4→partner) and Y-score (partner→TMPRSS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP21-2 →	+0.313	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUSC	DEFB4B →	+0.130	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUAD	CNMD →	+0.226	+3.605	.005	.007	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.016	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OTOS →	+0.063	+3.605	<.001	.007	3	1
LUNG_NSCLC_LUAD	MRGPRX4 →	+0.012	+3.604	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

KRTAP21-2 by TMPRSS4 expression — SOFT_TISSUE

Explore this box plot interactively →