TMPRSS11E

Across TCGA patient cohorts, TMPRSS11E RNA expression is significantly associated with the RNA expression of many other genes, with 8,763 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible TMPRSS11E-associated genes across cancer lineages are IVL, SPRR3, and PRSS22. Each is linked with TMPRSS11E in more than 20 cancer types. Because this analysis shows association rather than direction, both TMPRSS11E-to-partner and partner-to-TMPRSS11E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMPRSS11E versus IVL in ESCA, with a Pearson correlation of 0.82.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11E→partner) and Y-score (partner→TMPRSS11E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	IVL →	+4.752	+4.458	<.001	<.001	3	21
ESCA	SPRR3 →	+6.700	+4.280	<.001	<.001	3	21
UCS	PRSS22 →	+1.864	+0.381	<.001	.003	3	21
ESCA	IL36RN →	+3.345	+4.253	<.001	<.001	3	20
ESCA	LY6D →	+5.232	+3.996	<.001	<.001	3	20
ESCA	SPRR1A →	+6.741	+4.564	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,763 associations by consensus.

TMPRSS11E vs IVL — ESCA

Explore this scatter interactively →