TMPRSS11E

Across TCGA pan-cancer cohorts, TMPRSS11E RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TMPRSS11E data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TMPRSS11E RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMPRSS11E expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

LUSC, LUAD, and THYM are the cancer types where TMPRSS11E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.694	0.500	.003	42	view →
LUAD	DFS	Quartile	All	0.204	0.454	.006	37	view →
THYM	DFS	Quartile	All	0.692	0.929	.006	28	view →
OV	OS	Tertile	IV	0.538	0.281	.007	24	view →
UVM	DFS	Tertile	III,IV	0.213	0.733	.020	18	view →
SKCM	OS	Quartile	All	0.792	0.889	.005	14	view →
PAAD	DFS	Quartile	All	0.336	0.593	.004	11	view →
LIHC	DFS	Tertile	All	0.448	0.566	.009	11	view →
COAD	DFS	Median	IV	0.346	0.607	.028	9	view →
BRCA	OS	Quartile	III,IV	0.846	0.942	.018	8	view →
KIRP	OS	Tertile	All	0.556	0.743	.020	8	view →
DLBC	OS	Quartile	II,III,IV	0.350	0.895	.025	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TMPRSS11E–LUSC (DFS)

Open the LUSC breakdown →