TMPRSS11E

Across TCGA pan-cancer cohorts, TMPRSS11E RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TMPRSS11E’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMPRSS11E RNA is repressed in tumor relative to normal tissue. In most cancer types TMPRSS11E is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where TMPRSS11E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMPRSS11E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−2.991	<.001	11	view →
KIRC	All	III,IV	−0.174	<.001	11	view →
LUAD	Female	II,III,IV	+3.742	<.001	9	view →
THCA	Male	All	+1.963	<.001	8	view →
KICH	Female	All	+3.834	<.001	7	view →
LUSC	Male	All	+3.661	<.001	7	view →
READ	All	II,III,IV	+0.255	.012	3	view →
UCEC	All	All	+0.693	.024	2	view →
KIRP	Male	II,III,IV	−0.067	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TMPRSS11E–HNSC

Open the HNSC breakdown →