TMPRSS11E

Across TCGA patient cohorts, TMPRSS11E mutation is significantly associated with the RNA expression of many other genes, with 2,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11E-associated genes across cancer lineages are KIF9-AS1, FDX2, and RNU1-154P. Each is linked with TMPRSS11E in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS11E-to-partner and partner-to-TMPRSS11E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF9-AS1 grouped by TMPRSS11E-low versus TMPRSS11E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11E→partner) and Y-score (partner→TMPRSS11E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF9-AS1 →	+0.496	+2.871	<.001	.001	3	3
UCEC	FDX2 →	+0.483	+3.523	.002	<.001	3	2
BLCA	RNU1-154P →	+0.360	+4.588	<.001	.008	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
BLCA	RNU6-1106P →	+0.264	+6.040	<.001	.001	3	2
READ	NPLP1 →	+0.312	+5.421	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,791 associations by consensus.

KIF9-AS1 by TMPRSS11E expression — UCEC

Explore this box plot interactively →