TMPRSS11E

Across TCGA patient cohorts, TMPRSS11E mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11E-associated genes across cancer lineages are FoxM1, PKC-delta_pS664, and STAT3_pY705. Each is linked with TMPRSS11E in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11E-to-partner and partner-to-TMPRSS11E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TMPRSS11E-low versus TMPRSS11E-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11E→partner) and Y-score (partner→TMPRSS11E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.188	+1.874	.021	.047	3	2
UCEC	PKC-delta_pS664 →	-0.105	-2.999	.025	.035	3	2
UCEC	STAT3_pY705 →	-0.381	-2.502	<.001	.002	3	2
UCEC	VHL →	-0.786	-2.000	.003	.030	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.302	-1.906	.030	.016	3	1
UCEC	EGFR_pY1068 →	-0.313	-3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by TMPRSS11E expression — SKCM

Explore this box plot interactively →