TMPRSS11E

Across TCGA cell cohorts, TMPRSS11E RNA expression is significantly associated with the go_rna of many other GO terms, with 1,737 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMPRSS11E-associated GO terms across cancer lineages are Positive regulation of proteolysis, Small GTPase-mediated signal transduction, and Viral budding via host ESCRT complex. Each is linked with TMPRSS11E in more than 8 cancer types. Because this analysis shows association rather than direction, both TMPRSS11E-to-partner and partner-to-TMPRSS11E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of proteolysis grouped by TMPRSS11E-low versus TMPRSS11E-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11E→partner) and Y-score (partner→TMPRSS11E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of proteolysis →	+0.077	+0.688	<.001	.002	3	9
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.051	+1.772	<.001	<.001	3	9
PANCREAS	Viral budding via host ESCRT complex →	+0.088	+1.040	<.001	.005	3	9
LARGE_INTESTINE	Cell-substrate junction assembly →	+0.119	+0.667	<.001	.003	3	8
URINARY_TRACT	Response to indole-3-methanol →	+0.274	+2.137	<.001	.003	3	8
URINARY_TRACT	Cellular response to indole-3-methanol →	+0.226	+2.164	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,737 associations by consensus.

Positive regulation of proteolysis by TMPRSS11E expression — LARGE_INTESTINE

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