TMPRSS11E

Across TCGA cell cohorts, TMPRSS11E mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMPRSS11E-associated genes across cancer lineages are OR7D4, CRYGC, and PRR23B. Each is linked with TMPRSS11E in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11E-to-partner and partner-to-TMPRSS11E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7D4 grouped by TMPRSS11E-low versus TMPRSS11E-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11E→partner) and Y-score (partner→TMPRSS11E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	2
LUNG_SCLC	CRYGC →	+0.053	+5.643	<.001	.002	3	1
OVARY	PRR23B →	+0.013	+5.196	<.001	.005	3	1
OVARY	OR10G2 →	+0.026	+5.196	<.001	.005	3	1
SKIN	CELA3A →	+0.021	+3.217	<.001	.006	3	1
SKIN	TPPP2 →	+0.048	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR7D4 by TMPRSS11E expression — OVARY

Explore this box plot interactively →