TMPRSS11D

Across TCGA patient cohorts, TMPRSS11D mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11D-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and p62 Lck ligand. Each is linked with TMPRSS11D in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11D-to-partner and partner-to-TMPRSS11D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TMPRSS11D-low versus TMPRSS11D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11D→partner) and Y-score (partner→TMPRSS11D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.175	+3.178	.002	.010	3	2
UCEC	mTOR_pS2448 →	-0.162	-3.680	.003	.001	3	2
UCEC	p62 Lck ligand →	+0.515	+2.662	<.001	<.001	3	2
UCEC	Src_pY527 →	-0.355	-1.415	.028	.046	3	2
UCEC	4E-BP1_pT37_T46 →	-0.379	-1.861	.007	.049	3	2
UCEC	4E-BP1 →	+0.220	+3.169	.030	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by TMPRSS11D expression — COAD

Explore this box plot interactively →