TMPRSS11D

Across TCGA pan-cancer cohorts, TMPRSS11D RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TMPRSS11D data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher TMPRSS11D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMPRSS11D expression acts as an unfavorable survival marker, although some lineages such as LUSC and HNSC show a favorable association.

DLBC, ACC, and UVM are the cancer types where TMPRSS11D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	II,III,IV	0.600	0.865	.012	47	view →
ACC	OS	Quartile	All	0.226	0.679	<.001	43	view →
UVM	OS	Tertile	All	0.396	0.801	.006	39	view →
SKCM	OS	Tertile	All	0.813	0.911	<.001	33	view →
LUSC	DFS	Tertile	II,III,IV	0.466	0.251	.003	31	view →
KICH	OS	Median	II,III,IV	0.675	0.956	.014	28	view →
PCPG	DFS	Tertile	All	0.824	0.955	.004	27	view →
HNSC	DFS	Median	All	0.736	0.654	.015	22	view →
SCLC	DFS	Tertile	III,IV	0.233	0.863	.017	18	view →
THCA	OS	Quartile	II,III,IV	0.916	0.988	.011	17	view →
CESC	DFS	Quartile	All	0.817	0.613	.006	14	view →
SARC	DFS	Tertile	All	0.552	0.304	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TMPRSS11D–DLBC (OS)

Open the DLBC breakdown →