Across TCGA patient cohorts, TMPRSS11B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,561 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TMPRSS11B-associated GO terms across cancer lineages are Intermediate filament-based process, Intermediate filament organization, and Regulation of keratinocyte proliferation. Each is linked with TMPRSS11B in more than 8 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Intermediate filament-based process →	+0.072	+2.274	<.001	<.001	3	9
ESCA	Intermediate filament organization →	+0.123	+2.700	<.001	<.001	3	9
ESCA	Regulation of keratinocyte proliferation →	+0.051	+1.631	<.001	<.001	3	8
UVM	Negative regulation of protein ubiquitination →	+0.041	+0.006	<.001	.001	3	8
STAD	Leukocyte aggregation →	+0.052	+0.461	<.001	.001	3	8
ESCA	Epidermal cell differentiation →	+0.071	+2.867	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,561 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types