Across TCGA patient cohorts, TMPRSS11B protein abundance is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TMPRSS11B-associated genes across cancer lineages are DOK5, LOXL3, and SYT11. Each is linked with TMPRSS11B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOK5 →	-0.730	-0.760	.001	.001	3	1
LSCC	LOXL3 →	-0.934	-0.652	.001	.003	3	1
LSCC	SYT11 →	-1.105	-0.830	.006	<.001	3	1
LSCC	NEK3 →	-0.557	-0.721	<.001	.004	3	1
LSCC	CRTC3 →	-0.601	-0.794	<.001	<.001	3	1
LSCC	FTO →	-0.496	-0.916	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types