Across TCGA patient cohorts, TMPRSS11B mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11B-associated genes across cancer lineages are Bap1-c-4, Cyclin-B1, and INPP4B. Each is linked with TMPRSS11B in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Bap1-c-4 →	+0.251	+2.000	.026	.029	3	3
UCEC	Cyclin-B1 →	+0.793	+2.584	<.001	.001	3	3
UCEC	INPP4B →	-0.351	-3.584	.004	.002	3	3
UCEC	Caveolin-1 →	-0.601	-3.169	.031	.018	3	3
UCEC	Cyclin-E2 →	+0.137	+2.009	.033	.017	3	3
LUAD	MSH6 →	+0.752	+3.347	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types