Across TCGA cell cohorts, TMPRSS11B RNA expression is significantly associated with the go_rna of many other GO terms, with 334 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TMPRSS11B-associated GO terms across cancer lineages are Positive regulation of protein ubiquitination, Regulation of hypoxia-induced intrinsic apoptotic signaling pathway, and Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. Each is linked with TMPRSS11B in more than 4 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein ubiquitination →	+0.067	+0.066	.002	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.129	+0.077	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.129	+0.077	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	MHC class I protein complex assembly →	+0.099	+0.048	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	Peptide antigen assembly with MHC class I protein complex →	+0.099	+0.048	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	Extrinsic apoptotic signaling pathway via death domain receptors →	+0.113	+0.064	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types