Across TCGA cell cohorts, TMPRSS11B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMPRSS11B-associated genes across cancer lineages are KRTAP1-1, SSMEM1, and REG1B. Each is linked with TMPRSS11B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP1-1 →	+0.076	+4.450	.002	.004	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	1
SKIN	TGM6 →	+0.032	+3.345	<.001	.007	3	1
LUNG_SCLC	OR4N2 →	+0.026	+4.269	.002	.005	3	1
LUNG_SCLC	OR13D1 →	+0.035	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types