Across TCGA patient cohorts, TMLHE mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMLHE-associated genes across cancer lineages are DEFB104A, USP9YP10, and IGHVIII-11-1. Each is linked with TMLHE in more than 1 cancer types. Because this analysis shows association rather than direction, both TMLHE-to-partner and partner-to-TMLHE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMLHE→partner) and Y-score (partner→TMLHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	DEFB104A →	+0.149	+7.977	<.001	.007	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	IGHVIII-11-1 →	+0.159	+7.977	<.001	.007	3	1
HNSC	OR4X7P →	+0.174	+7.954	<.001	.008	3	1
LUAD	MIR124-3 →	+0.363	+7.930	<.001	.008	3	1
UCEC	IMMP1L →	+0.470	+2.917	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

Exploration

TMLHE survival (RNA) · tumor vs normal (RNA) · all TMLHE data types