Across TCGA pan-cancer cohorts, TMLHE RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TMLHE’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where TMLHE RNA is repressed in tumor relative to normal tissue. In most cancer types TMLHE is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
THCA, LUSC, and BRCA are the cancer types where TMLHE tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMLHE RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.