TMEM9

Across TCGA patient cohorts, TMEM9 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM9-associated genes across cancer lineages are A-Raf_pS299, S6_pS240_S244, and VHL. Each is linked with TMEM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM9-to-partner and partner-to-TMEM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TMEM9-low versus TMEM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM9→partner) and Y-score (partner→TMEM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.132	-3.000	.018	.036	3	1
UCEC	S6_pS240_S244 →	+0.619	+3.013	.001	.018	3	1
UCEC	VHL →	-0.926	-2.321	.003	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.640	+3.189	.020	.010	3	1
UCEC	Caspase-8 →	-0.248	-3.295	.034	.009	3	1
UCEC	Heregulin →	-0.149	-3.459	.009	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by TMEM9 expression — UCEC

Explore this box plot interactively →